Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humansArticle Published on 2022-12-052022-11-15 Journal: The Journal of Experimental Medicine [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antibody Antigen antigenic breadth Breakthrough infection Cell comparable Delta develop dose Effect elicit Frequency Human increase increases in individual Infection memory memory B memory B cell memory B cells memory response Memory responses mRNA mRNA vaccine omicron plasma antibody receive response responses SARS-CoV-2 severe COVID-19 [DOI] 10.1084/jem.20221006 PMC 바로가기
Antigenic mapping reveals sites of vulnerability on α-HCoV spike proteinArticle Published on 2022-11-042022-11-15 Journal: Communications Biology [Category] SARS, 진단, [키워드] antigenic appear characterized conserved distal domain dominant effective epitope Epitopes feasibility HCoV-229E HCoV-NL63 highlight human coronavirus imperative N-terminal domain Neutralizing neutralizing antibody panel of antibody Protein RBD Receptor binding domain receptor binding site recognize representing reveal S protein S proteins similarity spike Spike protein subset the SARS-CoV-2 understanding Vaccine design Vaccine development [DOI] 10.1038/s42003-022-04160-8 PMC 바로가기
Antibody response to COVID-19 vaccines among workers with a wide range of exposure to per- and polyfluoroalkyl substancesArticle Published on 2022-11-012022-11-15 Journal: Environment international [Category] 진단, [키워드] 95% CI adjusted affected analyses Analysis anti-Spike IgG antibody antigenic association coefficient comparable Concentration confidence interval Coronavirus disease 2019 COVID-19 COVID-19 antibody COVID-19 vaccination COVID-19 vaccine disease Enrollment examined follow-up study group Human IgG increase in interquartile range magnitude neutralizing antibody observation Occurrence other variables participant Perfluoroalkyl substances PFAS Polyfluoroalkyl substances recent reduced repeated measure reported response serum shown spring sulfonic acid Tetanus vaccination Vaccine vaccine-induced antibody vaccine. [DOI] 10.1016/j.envint.2022.107537 PMC 바로가기
A triple-RBD-based mucosal vaccine provides broad protection against SARS-CoV-2 variants of concernArticle Published on 2022-11-012022-11-15 Journal: Cellular and Molecular Immunology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] antibodies antigenic chimeric correlated Delta effective elicit flagellin Flagellin adjuvant human ACE2 IgA immunization Infection initial intranasal intranasal immunization Lower lung mucosal mucosal vaccine Mutation nasal neutralizing antibody neutralizing immunity omicron pathology Protein provide RBD reduce SARS-CoV-2 SARS-CoV-2 variant secretory IgA significantly specificity Spread tissue pathology transgenic mice transmission potential Triple-RBD Vaccine vaccine candidate variant Variant of concern. Viral RNA [DOI] 10.1038/s41423-022-00929-3 PMC 바로가기
Immunogenic properties of SARS-CoV-2 inactivated by ultraviolet lightArticle Published on 2022-11-012022-11-15 Journal: Archives of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] Antigen antigenic antigenic variant can be used COVID-19 diagnostic disease effective Effectiveness immunization immunogenic inactivated Inactivated vaccine inactivation induce mice morphology physical Protective reducing mortality SARS-CoV-2 Spread Treatment ultraviolet ultraviolet light Vaccine virus inactivation virus stock virus-neutralizing antibody [DOI] 10.1007/s00705-022-05530-7 PMC 바로가기
Bioinformatics pipeline unveils genetic variability to synthetic vaccine design for Indian SARS-CoV-2 genomesArticle Published on 2022-11-012022-11-15 Journal: International immunopharmacology [Category] SARS, 치료기술, 치료제, [키워드] aligned amino acid change antigenic antigenic epitopes B-cell epitope bioinformatics bioinformatics pipeline can be used clade clades conserved conserved regions criteria epitope Evolution genetic variability genomic HLA allele identify immunogenic MAFFT MHC-I MHC-II Multiple sequence alignment Mutation Nextstrain Non-synonymous Non-Synonymous Signature SNP performed Phylogenetic analysis primer probe Protein Region regions reported resulting SARS-CoV-2 SARS-CoV-2 genome SARS-CoV-2 pandemic selected SNP SNPs T-cell T-cell epitope T-cell epitopes T-cell epitopes. unique Vaccine Vaccine design virus virus detection virus genome [DOI] 10.1016/j.intimp.2022.109224 PMC 바로가기
Type D lymphomatoid papulosis with pityriasis lichenoides et varioliformis acuta-like features in a child with parvovirus infection: a controversial diagnosis in the spectrum of lymphoid proliferations: case report and literature reviewArticle Published on 2022-10-282022-11-16 Journal: Italian Journal of Pediatrics [Category] COVID19(2023년), SARS, 치료기술, [키워드] Administered Alanine antigenic Aspartate aminotransferase Bilirubin C-reactive protein Case report CD8+/CD30+ cells children clinical response clinical suspicion Critical cytokine profile Cytokines Department Diagnosis differential diagnosis discharged disease disorder Emergency erythematous feature Fever histological history Hospitalized IFN-γ IL-10 IL-6 immunoglobulin M infectious agent infiltration introduced Laboratory test lesion lesions limits literature review lymphoid lymphomatoid Lymphomatoid papulosis lymphoproliferative Lymphoproliferative cutaneous disorders marker mechanism monoclonal morphologically necrotic Parvovirus parvovirus B19 pathogenic Perspective phenotype pityriasis lichenoides et varioliformis acuta. polymerase chain reaction positive response proliferation Rash recorded regions reported representing returned SARS-CoV-2 antigen separated skin lesions steroid Support Symptom systemic corticosteroid T-cell receptor Therapies Treatment Type Type D [DOI] 10.1186/s13052-022-01371-x PMC 바로가기
Dissecting Naturally Arising Amino Acid Substitutions at Position L452 of SARS-CoV-2 SpikeArticle Published on 2022-10-262022-11-15 Journal: Journal of Virology [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] acid acute respiratory syndrome addition addressed Amino acid amino acid substitution antigenic Antisera Care caused characterized coronavirus COVID-19 death demonstrated expressing expression level fitness FIVE GISAID globe greater Health highlight host immunity identifying Immune escape immune evasion immunological profile initiative Intervention L452 less lineages maintain mutant Mutation mutational studies Naturally neutralization pandemic phenotypic position promote pseudovirus retrieved SARS-CoV-2 SARS-CoV-2 spike SARS-CoV-2 variant selected sensitivity sequence single nucleotide spike Spike protein Substitution substitution. T cell Transmissibility variants of concern viral evolution viral fitness viral infectivity virus VoC [DOI] 10.1128/jvi.01162-22 PMC 바로가기
Reduced Sensitivity of Commercial Spike-Specific Antibody Assays after Primary Infection with the SARS-CoV-2 Omicron VariantArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 진단, [키워드] addition Affect analyzed anti-SARS-CoV-2 anti-SARS-CoV-2 antibody antibodies antibody antibody assay Antibody assays antigenic antigenic structure antigens assays change changes in characterized controls convalescent individual correlation diagnostic immunoassay immunoassays immunoreactivity impairing individual Infection lack neutralization Neutralization assay Neutralizing activity Neutralizing antibodies Neutralizing antibody titer omicron Primary infection Protein quantified RBD reduced SARS-CoV-2 SARS-CoV-2-specific antibody sensitivity significantly spike statistically significant reduction subjects surrogate assay. tested the SARS-CoV-2 the Spike variant variants were used wild type wild-type wild-type strain [DOI] 10.1128/spectrum.02129-22 PMC 바로가기
SARS-CoV-2 infections elicit higher levels of original antigenic sin antibodies compared with SARS-CoV-2 mRNA vaccinationsArticle Published on 2022-10-182022-11-15 Journal: Cell Reports [Category] COVID19(2023년), SARS, 진단, [키워드] acute respiratory syndrome antibodies antibody antigenic assays boost coronavirus CP: Immunology cross-react determine elicit Health care worker human coronavirus human coronaviruses Infection magnitude mRNA mRNA vaccination mRNA vaccines original antigenic sin. participant proportion reactive responses SARS-CoV-2 SARS-COV-2 infection specificity vaccination [DOI] 10.1016/j.celrep.2022.111496 PMC 바로가기